A Case of Anaphylaxis Following Administration of Garenoxacin Mesylate Hydrate

A 64-year-old woman took Garenoxacin Mesylate Hydrate (GRN) 400 mg and several drugs for the treatment of upper respiratory tract infection. Two and a half hours later and soon after bathing, she suddenly noticed pruritis on her face and hands. After her arrival at emergency unit of our hospital, she developed dyspnea and wheezing accompanied by generalized erythema and wheals. Within one hour following treatment with methylprednisolone sodium succinate and chlorpheniramine maleate, her cutaneous and respiratory symptoms subsided. Prick tests using diluted saline solution of these drugs showed positive results with GRN, whereas the other drugs were negative. Oral challenge tests, which were performed with all the drugs except for GRN, showed negative results at therapeutic doses. Based on these results, she was diagnosed as anaphylaxis related to GRN. During one-year follow up period after avoiding quinolones, she has not experienced any episode of anaphylaxis. Although quinolone-related anaphylaxis is not uncommon, our case is the first case report describing precise clinical history of anaphylaxis related to GRN.